Biosynthesis of the Pyrroindomycins by Streptomyces rugosporus LL-42D005; Characterization of Nutrient Requirements.
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منابع مشابه
Biosynthesis of the pyrroindomycins by Streptomyces rugosporus LL-42D005; characterization of nutrient requirements.
Streptomyces rugosporus LL-42D005 was shown to produce the novel pyrroindomycin antibiotics. Production of pyrroindomycin (alpha) and chloro-pyrroindomycin (beta) was characterized in a semi-defined fermentation medium containing glucose, casein, phosphate, vitamins and minerals. Accumulation of pyrroindomycin beta increased with increasing concentrations of glucose, reaching maximum titers at ...
متن کاملPyrroindomycins, novel antibiotics produced by Streptomyces rugosporus LL-42D005. II. Biological activities.
The pyrroindomycins, a complex of novel antibiotics identified in fermentation broths of "Streptomyces rugosporus" LL-42D005, demonstrated excellent in vitro activity against Gram-positive bacteria. The semisynthetic diacetyl derivative of pyrroindomycin B (pyrroindomycin B-Ac2) was bactericidal for exponential-phase cells, but not for stationary-phase cells. This compound also exhibited margin...
متن کاملPyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.
Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1999
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.52.117